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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP2A
All Species:
6.06
Human Site:
S1392
Identified Species:
9.52
UniProt:
P11388
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P11388
NP_001058.2
1531
174385
S1392
K
G
S
V
P
L
S
S
S
P
P
A
T
H
F
Chimpanzee
Pan troglodytes
XP_516332
1634
184611
T1439
S
P
G
K
S
K
A
T
P
E
K
S
L
H
D
Rhesus Macaque
Macaca mulatta
XP_001092092
1620
182490
T1425
S
P
G
K
S
K
A
T
P
E
K
S
L
H
D
Dog
Lupus familis
XP_537646
1532
174610
S1393
A
K
D
S
V
P
L
S
P
G
S
T
A
D
F
Cat
Felis silvestris
Mouse
Mus musculus
Q01320
1528
172859
S1388
V
K
D
S
V
P
A
S
P
G
V
P
A
A
D
Rat
Rattus norvegicus
P41516
1526
173202
P1388
K
D
S
V
P
A
S
P
G
A
S
A
A
D
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519680
1746
195650
E1422
Q
Q
T
A
K
A
M
E
I
Q
S
S
D
T
S
Chicken
Gallus gallus
O42130
1553
174974
R1414
A
P
P
V
S
V
P
R
A
Q
A
V
P
K
K
Frog
Xenopus laevis
NP_001082502
1579
178601
K1407
E
N
A
P
P
K
N
K
A
V
P
D
I
E
I
Zebra Danio
Brachydanio rerio
NP_001003834
1574
177254
A1401
A
K
A
E
K
P
E
A
S
S
K
S
S
S
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P15348
1447
164377
A1308
T
S
P
K
A
K
K
A
V
V
K
K
E
P
G
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23670
1520
172316
G1377
S
K
P
K
P
R
T
G
K
G
A
A
K
A
E
Sea Urchin
Strong. purpuratus
XP_783546
1448
163750
K1309
S
D
K
P
A
G
A
K
P
K
T
K
T
A
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P30182
1473
164089
S1326
S
S
K
T
A
E
T
S
K
A
I
A
V
D
D
Baker's Yeast
Sacchar. cerevisiae
P06786
1428
164196
S1290
E
G
E
L
S
K
I
S
N
K
F
K
K
I
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
67.2
67.5
93.6
N.A.
89
88.7
N.A.
71.3
76.3
70.7
67.9
N.A.
51.2
N.A.
53
58.9
Protein Similarity:
100
78.6
78.4
96.4
N.A.
93.6
93.2
N.A.
79.1
85
81.8
78.8
N.A.
66.8
N.A.
70.4
73.4
P-Site Identity:
100
6.6
6.6
13.3
N.A.
6.6
40
N.A.
0
6.6
13.3
6.6
N.A.
0
N.A.
13.3
6.6
P-Site Similarity:
100
26.6
26.6
13.3
N.A.
13.3
40
N.A.
20
20
40
33.3
N.A.
6.6
N.A.
20
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
45
42.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
61.4
60.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
20
0
14
7
20
14
27
14
14
14
14
27
20
20
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
14
14
0
0
0
0
0
0
0
0
7
7
20
27
% D
% Glu:
14
0
7
7
0
7
7
7
0
14
0
0
7
7
7
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
7
0
0
0
14
% F
% Gly:
0
14
14
0
0
7
0
7
7
20
0
0
0
0
7
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
20
7
% H
% Ile:
0
0
0
0
0
0
7
0
7
0
7
0
7
7
7
% I
% Lys:
14
27
14
27
14
34
7
14
14
14
27
20
14
7
7
% K
% Leu:
0
0
0
7
0
7
7
0
0
0
0
0
14
0
0
% L
% Met:
0
0
0
0
0
0
7
0
0
0
0
0
0
0
0
% M
% Asn:
0
7
0
0
0
0
7
0
7
0
0
0
0
0
0
% N
% Pro:
0
20
20
14
27
20
7
7
34
7
14
7
7
7
7
% P
% Gln:
7
7
0
0
0
0
0
0
0
14
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
7
0
7
0
0
0
0
0
0
0
% R
% Ser:
34
14
14
14
27
0
14
34
14
7
20
27
7
7
14
% S
% Thr:
7
0
7
7
0
0
14
14
0
0
7
7
14
7
0
% T
% Val:
7
0
0
20
14
7
0
0
7
14
7
7
7
0
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _